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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH1
All Species:
12.19
Human Site:
S439
Identified Species:
20.63
UniProt:
P17752
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17752
NP_004170.1
444
50985
S439
S
D
A
L
A
K
V
S
R
K
P
S
I
_
_
Chimpanzee
Pan troglodytes
XP_001172877
875
97166
A439
S
D
A
L
A
K
G
A
N
S
Y
G
Q
L
G
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
N485
C
D
A
L
N
K
M
N
Q
Y
L
G
I
_
_
Dog
Lupus familis
XP_854768
828
92147
A480
S
D
A
L
A
K
G
A
N
S
Y
G
Q
L
G
Cat
Felis silvestris
Mouse
Mus musculus
P17532
447
51325
T442
S
D
A
L
A
R
V
T
R
W
P
S
V
_
_
Rat
Rattus norvegicus
P09810
444
51050
S439
N
D
A
L
A
R
V
S
R
W
P
S
V
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
S439
G
D
A
L
T
R
M
S
R
Q
L
G
V
_
_
Chicken
Gallus gallus
P70080
445
51121
G440
S
D
A
L
S
K
M
G
K
Q
L
E
V
_
_
Frog
Xenopus laevis
Q92142
481
55388
N476
N
D
A
L
N
K
M
N
K
Q
L
G
V
_
_
Zebra Danio
Brachydanio rerio
NP_840091
471
53899
T465
V
V
E
E
L
N
M
T
G
H
L
G
D
A
_
Tiger Blowfish
Takifugu rubipres
NP_001027848
479
54964
N474
S
D
A
L
C
R
L
N
K
Q
L
G
V
_
_
Fruit Fly
Dros. melanogaster
P17276
452
51642
V447
F
Q
I
L
Q
N
A
V
A
K
L
R
V
_
_
Honey Bee
Apis mellifera
XP_394674
508
57954
Q479
S
N
A
L
R
K
I
Q
E
Q
D
D
T
V
D
Nematode Worm
Caenorhab. elegans
P90925
457
52111
N452
E
E
A
L
G
K
V
N
N
L
K
M
K
_
_
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.5
64.6
52.5
N.A.
89.4
91.2
N.A.
85.3
85.8
75.2
72.8
71.6
51.1
57.2
48.3
N.A.
Protein Similarity:
100
50.6
79.3
53.1
N.A.
95.3
96.1
N.A.
93.6
95.5
87.3
83.6
84.1
71.4
71.6
68
N.A.
P-Site Identity:
100
40
38.4
40
N.A.
69.2
69.2
N.A.
38.4
38.4
30.7
0
30.7
15.3
26.6
30.7
N.A.
P-Site Similarity:
100
53.3
61.5
53.3
N.A.
92.3
92.3
N.A.
69.2
76.9
76.9
14.2
76.9
23
46.6
46.1
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
86
0
36
0
8
15
8
0
0
0
0
8
0
% A
% Cys:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
72
0
0
0
0
0
0
0
0
8
8
8
0
8
% D
% Glu:
8
8
8
8
0
0
0
0
8
0
0
8
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
8
0
15
8
8
0
0
50
0
0
15
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
8
0
0
0
0
0
15
0
0
% I
% Lys:
0
0
0
0
0
58
0
0
22
15
8
0
8
0
0
% K
% Leu:
0
0
0
93
8
0
8
0
0
8
50
0
0
15
0
% L
% Met:
0
0
0
0
0
0
36
0
0
0
0
8
0
0
0
% M
% Asn:
15
8
0
0
15
15
0
29
22
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
22
0
0
0
0
% P
% Gln:
0
8
0
0
8
0
0
8
8
36
0
0
15
0
0
% Q
% Arg:
0
0
0
0
8
29
0
0
29
0
0
8
0
0
0
% R
% Ser:
50
0
0
0
8
0
0
22
0
15
0
22
0
0
0
% S
% Thr:
0
0
0
0
8
0
0
15
0
0
0
0
8
0
0
% T
% Val:
8
8
0
0
0
0
29
8
0
0
0
0
50
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
15
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
72
79
% _